The Super Speciality Hospital (Sri Sathya Sai Institute of Higher Medical Sciences) was setup at Prasanthi Gram (about 9 kms. from Prasanthi Nilayam) under the auspices of the Sri Sathya Sai Medical Trust in the year 1991 to demonstrate that medical care of the highest quality even in highly specialised fields like Cardiology, Urology, Nephrology, Ophthalmology etc can be provided totally free of cost. The aim of the Trust is to ensure that ailing persons receive the best treatment, irrespective  of their caste, creed, or social status.

The Super-Speciality hospital acts as a nucleus for the extension of primary health care at village levels in the surrounding areas. Sri Sathya Sai General Hospital at Prasanthi Nilayam and Sri Sathya Sai Hospital at Whitefield, Bangalore extend the secondary health care and finally the Super-Speciality Hospital acts as the tertiary link in the chain of total health care.

Some of the interesting surgeries performed in this department:

• Mobile left atrial clot with Rheumatic mitral stenosis.
• Left ventricle to aorta tunnel.
• Anomalous left coronary artery arising from pulmonary artery.
• Arterial switch.
• Aortopulmonary window.
• Coronary artery bypass grafting with Radical Rt.Hemicolectomy Ascending aorta and arch replacement for chronic dissecting aneurysm.
• Repair of a huge ascending aorta aneurysm that had eroded the chest wall.